Pick your one guitar, one pedal and one amp...

[Fiddy]

Fernandes Mustang
Princeton Reverb
Deep Blue delay

Edit:

From a few year ago...

Yamaha SG2 or 3, Ibanez AD9 Delay, Silverface Vibrolux.

[BobL]

From my stuff...

Gretsch CS G6128T, though both my tele and my JM could make strong arguments...
Tuner
Tone King Imperial

[ifallalot]

[Singlebladepickup]

Jazzmaster (Custom Shop, vintage, boutique, or just the parts guitar I've got)
Gomez G-Reverb (or my SFPR, a BFPR, secret agent or some other boutique Princeton Reverb clone)
Fairfield Shallow Water or CB Thermae (I have neither)

[marqueemoon]

Lipstick JM
Madbean Moar
Blackface PR clone head with an open back 1x12

I actually prefer plate verb sounds, but that would give me verb and trem without sacrificing a pedal choice. Gotta be a head/cab setup though so they can be mechanically isolated.

[tinybobseger]

jaguar, caroline shigaharu, twin reverb

[jesterpunk68]

If I was going from my own gear

Gretsch G5191 Tim Armstrong

Vox AC15c2

Joyo JF-08 Digital Delay Effect Pedal

Although my squier vm jazzmaster would be my second option once I get done modding it, going to put a mastery bridge, wide range hum buckers and replace the lead switch with a 2 way toggle like the TVL jazzy has.

[cestlamort]

(Something not terrible) > big box dmm > (something not terrible).

[countertext]

Gretsch 6122
PROCO RAT
Marshall JCM800 + 4x12

[edwardskim]

Sherwood Green Johnny Marr Jaguar
Carl Martin DeLayla XL
68 PRRI

[leokula]

(Something not terrible) > big box dmm > (something not terrible).

[Squirrel]

Gretsch Tennessean
Uhh, I dunno, some tuner pedal
Fender Tremolux

[SadFuzz]

Jazzmaster>Harmonic Percolator>Silverface Twin or a JC-160

[DiAmoroso]

There are a lot of amps and pedals out there I have never tried, but with my current knowledge level I'd go:

Am Pro Jaguar - Line6 DL4 - Orange TH30H and open back 212 cab

I'm assuming here the channel footswitch doesn't count as a pedal. If it does, switching between clean and dirty is most important for me.

[countertext]

Rickenbacker 4001
Maestro Bass Brassmaster
Ampeg SVT